2015). These research, taken together, counsel that, Though a immediate activation of GPR55 or PPAR‐α takes place, PEA can deliver its anti‐inflammatory motion while in the intestine also by way of oblique activation of CB1 and CB2 receptors, possibly due to the flexibility of this compound to potentiate the motion of endocannabinoids at these
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2005). These results weren't surprising if we take into consideration that PEA can be a inadequately water‐soluble material, which often can Restrict its oral absorption and bioavailability, Nonetheless they may propose a brief‐lived action of PEA, in agreement with The reality that this compound is degraded by two diverse hydrolases, that may
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